By Hala Gali-Muhtasib
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This interaction allows MHC and co-stimulatory molecules to bind to their receptors on the T cells long enough to provide sufficient signaling. , 2004). 2 Transfer of antigens by exosomes In addition to their ability to present processed antigens, exosomes can also transfer antigens from one cell to another. , 2006). This is a very important mechanism in disease states, where infected or malignant cells release exosomes into the bloodstream that can be processed and presented by APCs throughout the body to induce an immune response (Bhatnagar & Schorey, 2007).
2007). Tie2-expressing monocytes: regulation of tumor angiogenesis and therapeutic implications. Trends in Immunology. 28, No. 12, (2007 December), pp. 519-524. ISSN: 1471-4906 Özdemir, Ö. (2006). Mast cell density, angiogenesis and their significance in tumor development. Gynecologic Oncology. 3, (2006 March), pp. 628–629. , Turay David and Wall Nathan R. Loma Linda University, Dept. of Biochemistry, Ctr. for Health Disparities & Mol. Loma Linda, California, United States of America 1. Introduction Cancer, a leading cause of death globally, is projected to become more prevalent in coming years due to increasing life expectancy.
Many types of vesicles have been described in the literature having quite heterogeneous size, protein content, RNA content and origin. , 2010). , 2010). Exosomes are nanometer sized lipid bound vesicles derived from late endosomes contained in MVB’s. , 2011) and their specific protein content (heat shock proteins, tetraspanins, Rab proteins, etc) Figure 1. Exosomes are secreted by both hematopoietic (eg dendritic cells, lymphocytes, mast cells) and non-hematopoietic cells such as fibroblasts, intestinal epithelium, neurons and various tumor cells.