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Acne Vulgaris by Alan R. Shalita, James Q. Del Rosso, Guy Webster

By Alan R. Shalita, James Q. Del Rosso, Guy Webster

The American zits and Rosacea Society is devoted to advancing the technology regarding pimples and rosacea and to improving communique among these drawn to those illnesses. this article isn't intended to be a finished treatise on all elements of pimples, yet quite to handle significant sights by means of said suggestion leaders within the box within the desire that it'll result in additional examine, dialogue, and refinement of our innovations of either the pathogenesis and the therapy of acne.

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48. Webster GF. Inflammation in acne vulgaris. J Am Acad Dermatol 1995; 33: 247 253. 49. Eady EA, Ingham E, Walters CE, et al. Modulation of comedonal levels of interleukin 1 in acne patients treated with tetracyclines. J Invest Dermatol 1993; 101:86 91. 50. Kealey T, Guy R. Modeling the infundibulum in acne. J Invest Dermatol 1997; 108:376. 51. Aldana OL, Holland DB, Cunliffe WJ.

The flow of sebum transports them to the surface of the skin upon desquamation, maintaining a balance between new and desquamated keratinocytes. However, in comedones, this balance is disturbed, leading to keratinocyte accumulation in the pilosebaceous duct. Hyperproliferation of basal keratinocytes, which line the wall of the infrainfundibulum, plays a central role in this accumulation (6,7). As more keratinous material accumulates, the follicular wall continues to distend and become thinner. Concurrently, sebaceous glands begin to atrophy and are replaced by undifferentiated epithelial cells.

J Invest Dermatol 1996; 106:176 182. 10. Trivedi NR, Gilliland KL, Zhao W, et al. Gene array expression profiling in acne lesions reveals marked upregulation of genes involved in inflammation and matrix remodeling. J Invest Dermatol 2006; 126:1071 1079. 11. Gollnick H, Cunliffe W, Berson D, et al. Management of acne: a report from a Global Alliance to Improve Outcomes in Acne. J Am Acad Dermatol 2003; 49:S1 S37. 12. Thiboutot D, Chen W. Update and future of hormonal therapy in acne. Dermatology 2003; 206:57 67.

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